科研之友
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摘要
Background: Previous observations suggest suboptimal 'real world' survival outcomes for advanced pancreatic adenocarcinoma. We hypothesized that centralisation of advanced pancreatic adenocarcinoma management would improve chemotherapy treatment and survival from the disease. Methods: The data was prospectively collected on all cases of advanced pancreatic adenocarcinoma reviewed through Clatterbridge Cancer Centre according to two groups; 1 October 2009-31st Dec 2010 (devolved care) or 1 January 2013-31 March 2014 (centralised care). Analysis included treatment received, 30-day chemotherapy mortality rate and overall survival (OS). Results: More patients received chemotherapy with central care (67.0% (n = 115) vs 43.0% (n = 121); P = 2.2 x 10(-4)) with no difference in 30-day mortality (20.8% vs 25%; P = 0.573) but reduced time to commencement of chemotherapy (18 vs 28 days, P = 1.0 x 10(-3)). More patients received second-line chemotherapy with central care (23.4% vs 1.9%, P = 1.4 x 10(-4)), while OS was significantly increased with central care (median: Five vs three months, HR 0.785, P = 0.045). Exploratory analysis suggested that it was those with a poorer performance status, elderly or with metastatic disease who benefited the most from transition to central care. Conclusions: A centralised clinic model for advanced pancreatic cancer management resulted in prompt, safe and higher use of chemotherapy compared with devolved care. This was associated with a modest survival benefit. Prospective studies are required to validate the findings reported and the basis for improved survival with centralised care.
- 出版日期2017-2-14
