Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms

作者：Halmai Zsuzsa; Dome Peter; Vereczkei Andrea; Abdul Rahman Omar; Szekely Anna; Gonda Xenia; Faludi Gabor; Sasvari Szekely Maria; Nemoda Zsofia^*

来源：Journal of Affective Disorders, 2013, 150(1): 104-109.

DOI：10.1016/j.jad.2013.02.033

• Major depressive disorder
• Bipolar disorder
• Purinergic receptor
• Genetic association analysis
• Depression symptom severity

Background: Major depressive disorder (MDD) and bipolar disorder (BPD) have significant genetic predisposition. The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a susceptibility gene for both MDD and BPD. In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3%26apos; untranslated region of the P2RX7 gene) were explored in mood disorders. %26lt;br%26gt;Methods: Genotype frequencies were established in 315 patients (195 with MDD and 120 with BPD diagnosis) and in 373 controls. Depression severity was assessed by the clinician-rated Montgomery-Asberg Depression Rating Scale (MADRS) and by the self-report Hospital Anxiety and Depression Scale (HADS). %26lt;br%26gt;Results: In the case-control analysis we did not find any significant differences between genotype frequencies of either BPD or MDD cases and controls. However, BPD patients carrying at least one rs2230912 G-allele scored higher on both MADRS and HADS-depression scale (nominal p-value was 0.028 and 0.003, respectively). The rs1653625 AA genotype was also associated with higher depression scores in the BPD group (nominal p-value of MADRS: 0.019, HADS-depression: 0.017). After correction for multiple testing, the association between rs2230912 and HADS-depression score remained significant in the BPD group (p %26lt; 0.006); this genetic effect explained 9% of the variance (partial eta(2)=0.09). In the MDD group we did not find any significant genetic effect. %26lt;br%26gt;Limitations: The relatively small number of BPD patients warrants for a replication study. %26lt;br%26gt;Conclusions: Our genetic association study supports the association between P2RX7 gene and severity of depressive symptoms in BPD patients.

• 出版日期2013-8-15
• 单位河北医科大学