Analysis of clinical characteristics of 516 patients with non-Hodgkin's lymphoma in Shanghai area

作者：Lin Zhiguang; Chen Bobin^*; Xu Xiaoping; Wang Xiaoqin; Lin Guowei

来源：Hematology, 2014, 19(2): 99-106.

DOI：10.1179/1607845413Y.0000000097

• Lymphoma
• Non-Hodgkin
• Epidemiologic studies
• Immunophenotyping
• Cytogenetic analysis
• In situ hybridization
• Fluorescence

The aim was to determine the clinical and cytogenetic characteristics of non-Hodgkin's lymphoma (NHL) in Shanghai. A retrospective analysis was conducted in 516 patients with NHL. Patient clinical data, including age, sex, diagnosis, immunophenotypes, and karyotypes, were collected. The median age was 58 years. There was a male predominance in all NHL, except extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. Patients with B cell NHL (1.5%) expressed CD3. T cell NHL patients (11.5%) expressed CD20. Epstein-Barr virus latent integral membrane protein 1, BCL6, CD10, Bcl-2, CD68, myeloperoxidase, CD99, CD30, CD15, and CD43 were present in various types of NHL. Complex karyotypes accounted for 92.3% of the 73.7% patients with abnormal karyotypes. Immunoglobin heavy chain gene translocation was present in 60.3% of B cell and 23.7% of T/NK cell neoplasms. Understanding the complex clinicopathological and molecular features of NHL may help with prognosis and serve as targets for treatments.

• 出版日期2014-3
• 单位复旦大学