An Asymmetric Hetero-Claisen Approach to 3-Alkyl-3-aryloxindoles

作者:Duguet Nicolas; Slawin Alexandra M Z; Smith Andrew D*
来源:Organic Letters, 2009, 11(17): 3858-3861.
DOI:10.1021/ol901441t

摘要

The reaction of a chiral N-phenylnitrone derived from Garner's aldehyde with alkylarylketenes generates 3-alkyl-3-aryloxindoles directly in excellent yields and with good to excellent levels of enantioselectivity (up to 90% ee).

  • 出版日期2009-9-3