A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid as biomaterials for drug delivery

作者：Liu Chia Chang; Chang Ken Yuan; Wang Yng Jiin^*

来源：Journal of Polymer Research, 2010, 17(4): 459-469.

DOI：10.1007/s10965-009-9332-5

• Amphiphilic diblock copolymer
• Poly(lactic acid)
• Hyaluronic acid
• Polymeric micelle
• Skin penetration

An amphiphilic poly((lactic acid)-b-hyaluronic acid) diblock copolymer, poly(LA-b-HA), was synthesized from short-chain hyaluronic acid and poly(lactic acid). The synthesis was conducted by coupling the N, N'- dicyclohexylcarbodiimide activated poly(lactic acid) to a short-chain hyaluronic acid which was pre-aminated with 1, 2-ethylenediamine at the reducing end followed by NaCNBH(3) reduction. The poly (LA-b-HA) copolymers synthesized were verified by the spectral analyses of FTIR and (1)H NMR. The poly(LA-b-HA) molecules can self-assemble into micelles in aqueous solution. The average diameters of polymeric micelles were estimated to be 116 /- 17 and 98 /- 11 nm for the polymeric micelles derived from the poly(lactic acid)s of MW 3,200 and MW 16,900, respectively. The poly(LA-b-HA) copolymeric material is non-cytotoxic and can be used as micellar drug carriers. The drug encapsulation capabilities of these poly(LA-b-HA) micelles were demonstrated by using ellagic acid and lidocaine chloride as model compounds. These new biodegradable micelles have a great potential to be used as drug delivery carrier for biomedical applications.

• 出版日期2010-7