Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats

作者：Wang, Peng; Li, Xiao-Tao; Sun, Lei; Shen, Lei^*

来源：Evidence-Based Complementary and Alternative Medicine, 2013, 2013: 164817.

DOI：10.1155/2013/164817

• NITRIC-OXIDE SYNTHASE
• EXPRESSION
• INFLAMMATION
• OSTEOPOROSIS
• FRACTURES
• MUSHROOM
• IMPROVES

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks. Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF-kappa B) level, polymorphonuclear (PMN) cells level, interleukin-1 beta (IL-1 beta) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor-alpha (TNF-alpha) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. WSP-AbM administration markedly (P < 0.05) decreased serum IL-1 beta and TNF-alpha levels and the expressions of ICAM-1, COX-2, and iNOS NF-kappa B compared with OVX rats. WSP-AbM administration alsomarkedly (P < 0.05) decreased PMN infiltration. In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease.

• 出版日期2013
• 单位佳木斯大学; 齐齐哈尔医学院; 哈尔滨医科大学