Moisturizing effect of stable cream containing Crocus sativus extracts

作者：Akhtar Naveed; Khan Haji Muhammad Shoaib; Ashraf Shoaib; Mohammad Imran Shair^*; Najam us Saqib; Bashir Kamran

来源：Pakistan Journal of Pharmaceutical Sciences, 2014, 27(6): 1881-1884.

• Crocus sativus
• oil in water emulsion
• physical stability
• skin moisture
• transepidermal water loss

The present study is about to prepare stable cream of water-in-oil emulsion containing extracts of Crocus sativus against its base (without extracts) taken as control, to determine its stability on different storage conditions and effects on skin moisture contents and transepidermal water loss. The formulation contains 3% Crocus sativus (Saffron) concentrated extracts, and the base containing no extract, were formulated. Different stability tests were done on samples, which placed at 8 degrees C, 25 degrees C, 40 degrees C and 40 degrees C with 75% relative humidity, for 4 week period. These formulations (Creams) were applied on the cheeks of human volunteers for 8week period. To evaluate any effect produced by these formulations different skin parameters were monitored every week. The significant results of this study explored the fact that water-in-oil emulsion topical cream of saffron formulated from Crocus sativus extract has absolute physical stability at different storage conditions. The increase in skin moisture contents and changes in transepidermal water loss were significant (p <= 0.05) with respect to base and formulation respectively. Topical cream of Crocus sativus showed significant moisturizing effects on human skin.

• 出版日期2014-11