Modular Access to N-Substituted cis-3,5-Diaminopiperidines

作者：Blond Aurelie; Dockerty Paul; Alvarez Raquel; Turcaud Serge; Lecourt Thomas; Micouin Laurent^*

来源：Journal of Organic Chemistry, 2013, 78(23): 12236-12242.

DOI：10.1021/jo401994y

A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.

• 出版日期2013-12-6