Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence

作者：Goldstein Ellie J C^*; Citron Diane M; Tyrrell Kerin L

来源：Antimicrobial Agents and Chemotherapy, 2014, 58(2): 1187-1191.

DOI：10.1128/AAC.02184-13

We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 mu g/ml and were not species related. SMT might have less impact on normal gut microbiota than other Clostridium difficile infection (CDI) antimicrobials.

• 出版日期2014-2