Molecular Imaging of alpha(1) Receptors In Vivo: Current Status and Perspectives

作者：Brust, P.^*; Deuther-Conrad, W.; Lehmkuhl, K.; Jia, H.; Wuensch, B.

来源：Current Medicinal Chemistry, 2014, 21(1): 35-69.

• Brain
• chaperone
• cancer
• disease
• fluspidine
• molecular imaging
• positron emission tomography
• sigma receptor
• signalling
• single photon emission computed tomography
• therapy

It is widely accepted that sigma (alpha) receptors represent a new and different avenue in the possible pharmacological treatment of cancer and several brain-related disorders. Of the two different alpha receptor types the alpha(1) receptors are assumed to be of major impact for brain diseases. Molecular imaging of brain alpha(1) receptors with positron emission tomography (PET) or single photon emission computed tomography (SPECT) may provide a significant contribution to the understanding of the cross-talk between alpha(1) receptors and inter-and intracellular signalling systems. New insights into these functional interrelationships will allow a better diagnosis of brain and cancerous diseases and direct a rational development of new therapeutic concepts.

• 出版日期2014-1
• 单位北京师范大学