Acute antioxidant pre-treatment attenuates endothelial microparticle release after decompression

作者：Chrismas Bryna C R; Midgley Adrian W; Taylor Lee; Vince Rebecca V; Laden Gerard; Madden Leigh A^*

来源：Diving and Hyperbaric Medicine, 2010, 40(4): 184-188.

• Decompression
• endothelium
• antioxidants
• treatment diving research

(Chrismas BCR, Midgley AW, Taylor L, Vince RV, Laden G, Madden LA Acute antioxidant pre-treatment attenuates endothelial microparticle release after decompression Diving and Hyperbaric Medicine 2010,40(4) 184-8)
Purpose The hyperbaric and hyperoxic effects of a dive have been demonstrated to elicit changes in oxidative stress, endothelial function and microparticle (MP) release Endothelial MP, which are small membrane vesicles shed from the endothelium, have been suggested as a valid in vivo marker of endothelial function Furthermore, recent research has shown an increase in CD 105 MP post-dive to be associated with a decline in endothelial function The aim of this study was to ascertain whether antioxidant (AOX) pre-treatment can attenuate increased CD105 MP release post-dive
Methods Five healthy, male, pressure-naive subjects completed two simulated dives (control and intervention) breathing compressed air to a depth of 18 metres' sea water for 80 min For the intervention dive, all subjects received a commercially available AOX pill containing vitamins C and E, selenium and beta-carotene 2 h pre-dive CD105 MP, total antioxidant capacity (TAC) and thiobarbituric reactive substances assay (TBARS) were determined pre-dive, at depth, immediately and 4 h post-dive
Results In the control dive, there was a significant increase in CD 105 MP immediately post-dive when compared with at depth (P < 0 001) and pre-dive (P = 0 039) values Antioxidant pre-treatment significantly attenuated this release of CD105 MP post-decompression (P = 0 002) There were no significant changes in TBARS or TAC
Conclusion These results may provide evidence of the potential use of AOX pre-treatment as an effective endothelial pre-conditioner for divers

• 出版日期2010-12