Process Analytical Technology (PAT) for enhanced development and control of continuous processes

作者：Goode Jon; Hebrault Dominique^*

来源：Chimica Oggi-Chemistry Today, 2012, 30(6): 20-+.

• PAT (Process Analytical Technology)
• flow chemistry
• mid-infrared (IR) spectroscopy
• ATR-FTIR
• real time in situ monitoring
• Reaction conditions screening
• Knoevenagel reaction
• Polymer Supported Reagents

In chemical development, the need for improvements in product quality, process safety and overall synthetic efficiency have become key factors in driving chemists and engineers to seek alternative technologies. Continuous flow reactor technologies provide the opportunity to significantly expand the scope of possible chemistries at laboratory scale, and allow for rapid testing, optimization, and scaling. However, a limiting factor relates to inline monitoring which is of great importance with respect to optimization and flow process understanding. One of the most convenient and nondestructive methods for real-time inline monitoring is mid-infrared (IR) spectroscopy, increasingly utilized to investigate chemistries challenging to analyze using standard offline techniques. Through several case studies, this article describes laboratory applications using instruments specifically designed for the in situ, real-time monitoring of flow chemistry.

• 出版日期2012-12