DeoT, a DeoR-type transcriptional regulator of multiple target genes

作者：Elgrably Weiss M; Schlosser Silverman E; Rosenshine I; Altuvia S^*

来源：FEMS Microbiology Letters, 2006, 254(1): 141-148.

DOI：10.1111/j.1574-6968.2005.00020.x

• yciT
• DeoR
• transcription control
• operon
• repression
• global regulator

In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid P-oxidation and peptide degradation.

• 出版日期2006-1