Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity

作者：Zhang, Min; Li, Xiao-Li; Li, Heng; Wang, Shan; Wang, Cong-Cong; Yue, Long-Tao; Xu, Hua; Zhang, Peng; Chen, Hui; Yang, Bing; Duan, Rui-Sheng^*

来源：Journal of Neuroimmunology, 2016, 293: 129-136.

DOI：10.1016/j.jneuroim.2016.03.002

• A(2A) receptor
• Experimental autoimmune neuritis
• CGS21680

Accumulated evidence demonstrated that Adenosine A(2A) receptor (A(2A)R) is involved in the inflammatory diseases. In the present study, we showed that a selective A(2A)R agonist, CGS21680, exacerbated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin. The exacerbation was accompanied with reduced CD4(+)Foxp3(+) T cells, increased CD4(+) CXCR5(+) T cells, B cells, dendritic cells and antigen-specific autoantibodies, which is possibly due to the inhibition of IL-2 induced by CGS21680. Combined with previous studies, our data indicate that the effects of A(2A)R stimulation in vivo are variable in different diseases. Caution should be taken in the use of A(2A)R agonists.

• 出版日期2016-4-15
• 单位泰安市中心医院; 山东大学; 山东省千佛山医院