Lymphoma of the pituitary stalk

作者：Krypciak S; Alonso E; Berle M; Ajzenberg C; Combes C; Caillet P; Taillandier Heriche E; Paillaud E^*

来源：Revue de Medecine Interne, 2010, 31(2): 140-145.

DOI：10.1016/j.revmed.2009.05.006

• Lymphomas
• Pituitary stalk

Introduction. - Tumors of the pituitary stalk are rare and their diagnosis is sometimes difficult.
Case report. - We report a case of it primary lymphoma of the pituitary stalk in a 78-year-old patient. To our knowledge, only seven similar cases have been previously published: prominent symptoms were headache, fatigue and diplopia; biologically, anterior pituitary low secretion or hyperprolactinemia were found in the majority of cases; regarding the imaging, only three patients presented an initial and isolated lesion of the stalk; histological evidence was obtained by a trans-sphenoidal biopsy in case of hypothalamic or pituitary associated lesion or by a trans-cranial biopsy in the event of an isolated lesion. As an alternative, a lumbar puncture could be performed; although less invasive, its diagnostic performance is lower.
Conclusion. - Current treatment relies on chemotherapy with intravenous methotrexate associated with intrathecal methotrexate infusion if cerebrospinal showed abnormal cells. Unfortunately, the results remain poor with a median survival of 9 months.

• 出版日期2010-2