Mechanisms of CaMKII action in long-term potentiation

作者：Lisman John^*; Yasuda Ryohei; Raghavachari Sridhar

来源：Nature Reviews Neuroscience, 2012, 13(3): 169-182.

DOI：10.1038/nrn3192

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds to NMDA-type glutamate receptors and produces potentiation by phosphorylating principal and auxiliary subunits of AMPA-type glutamate receptors. These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse.

• 出版日期2012-3