Acceleration of Long-Range Photoinduced Electron Transfer through DNA by Hydroxyquinolines asArtificial Base Pairs

作者：Baetzner Effi; Liang Yu; Schweigert Caroline; Unterreiner Andreas Neil^*; Wagenknecht Hans Achim

来源：ChemPhysChem, 2015, 16(8): 1607-1612.

DOI：10.1002/cphc.201500062

• base pairs
• electron transfer
• oligonucleotides
• photochemistry
• transient absorption spectroscopy

The C-nucleoside based on the hydroxyquinoline ligand (Hq) is complementary to itself and forms stable Hq-Hq pairs in double-stranded DNA. These artificial Hq-Hq pairs may serve as artificial electron carriers for long-range photoinduced electron transfer in DNA, as elucidated by a combination of gel electrophoretic analysis of irradiated samples and time-resolved transient absorption spectroscopy. For this study, the Hq-Hq pair was combined with a DNA-based donor-acceptor system consisting of 6-N,N-dimethylaminopyrene conjugated to 2-deoxyuridine as photoinducible electron donor, and methyl viologen attached to the 2-position of uridine as electron acceptor. The Hq radical anion was identified in the time-resolved measurements and strand cleavage products support its role as an intermediate charge carrier. Hence, the Hq-Hq pair significantly enhances the electron hopping capability of DNA compared to natural DNA bases over long distances while keeping the self-assembly properties as the most attractive feature of DNA as a supramolecular architecture.

• 出版日期2015-6-8