A note on the calculation of reference change values for two consecutive normally distributed laboratory results

作者：M Regis; Th A Postma; E R van den Heuvel

来源：Chemometrics and Intelligent Laboratory Systems, 2017, 171: 102-111.

DOI：10.1016/j.chemolab.2017.10.008

• Monitoring
• Change-point detection
• Heterogeneity
• Heteroscedasticity
• Critical difference
• Reference change values

Abstract(#br)Population reference limits are inadequate for personalized analyses of medical laboratory results. Reference change values have been recommended as a valid alternative in assessing individual changes across sequential measurements. In this paper, we investigate the accuracy (type I err...

• 出版日期2017