A cross-metathesis route to functionalized alpha-methyl alpha-substituted amino acids

作者：Storcken Roy P M; Panella Lavinia; van Delft Floris L; Kaptein Bernard; Broxterman Quirinus B; Schoemaker Hans E; Rutjes Floris P J T^*

来源：Advanced Synthesis & Catalysis, 2007, 349(1-2): 161-164.

DOI：10.1002/adsc.200600446

• amino amidase
• cross-metathesis
• enzyme catalysis
• alpha-methyl alpha-substituted amino acids
• side-chain omega-unsaturated alpha-amino acids

A chemoenzymatic approach to the synthesis of functionalized alpha-methyl alpha-substituted amino acids is detailed. This involves amidase-mediated enzymatic resolution of alpha-methyl alpha-substituted side-chain omega-unsaturated amino acids followed by functionalization via cross-metathesis.

• 出版日期2007-1