An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

作者：Yoon Aerin; Yi Kye Sook; Chang So Young; Kim Sung Hwan; Song Manki; Choi Jung Ah; Bourgeois Melissa; Hossain M Jaber; Chen Li Mei; Donis Ruben O; Kim Hyori; Lee Yujean; Hwang Do Been; Min Ji Young; Chang Shin Jae; Chung Junho^*

来源：PLos One, 2015, 10(10): e0141312.

DOI：10.1371/journal.pone.0141312

To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.

• 出版日期2015-10-29