Development of one-pot three component reaction for the synthesis of N '-aryl-N-cyanoformamidines, essential precursors of formamidine pesticides family

作者：De Nino Antonio^*; Maiuolo Loredana^*; Nardi Monica; Pasceri Raffaele; Procopio Antonio; Russo Beatrice

来源：Arabian Journal of Chemistry, 2016, 9(1): 32-37.

DOI：10.1016/j.arabjc.2015.06.016

• Cyanoformamidines
• Pesticides
• One-pot reaction
• Labelled compounds

Efficient one-pot three component reaction of aniline derivatives with cyanoamide and triethyl orthoformate at reflux in toluene affords N'-aryl-N-cyanoformamidines in high yields just by the distillation of the azeotrope toluene/ethyl alcohol. Labelled d(9)-Amitraz is prepared by the application of this procedure in the synthesis of formamidine pesticides family.

• 出版日期2016-1