Decreased Prohepcidin Levels in Patients with HBV-Related Liver Disease: Relation with Ferritin Levels

作者：Yonal Oya^*; Akyuz Filiz; Demir Kadir; Ciftci Sevgi; Keskin Fahriye; Pinarbasi Binnur; Uyanikoglu Ahmet; Issever Halim; Ozdil Sadakat; Boztas Gungor; Besisik Fatih; Kaymakoglu Sabahattin; Cakaloglu Yilmaz; Mungan Zeynel; Okten Atilla

来源：Digestive Diseases and Sciences, 2010, 55(12): 3548-3551.

DOI：10.1007/s10620-010-1183-8

• Prohepcidin
• Iron
• Hepatitis B
• Cirrhosis

Levels of prohepcidin, a homeostatic regulator of iron absorption, are altered in chronic hepatitis C and liver cirrhosis. However, data on the potential alterations of prohepcidin in patients with HBV-related liver disease are scarce. We investigated whether serum prohepcidin is related to iron overload and perenchymal dysfuction in HBV-related liver disease.
Three groups of subjects were studied: 66 patients with chronic hepatitis B, 32 patients with HBV-related cirrhosis, and 42 healthy controls without evidence of liver disease. Serum levels of prohepcidin were determined by enzyme-linked immunosorbent assay.
Serum prohepcidin levels were significantly lower in patients with HBV-related cirrhosis (175.85 +/- A 71.5 ng/ml) than in patients with chronic hepatitis B (209.02 +/- A 62.7 ng/ml P < 0.05) and controls (222.4 +/- A 128.4 ng/ml, P < 0.05). After adjustment for potential confounders, prohepcidin was found to be an independent predictor of ferritin levels in multiple linear regression analysis (beta = -1.10, t = -3.11, P < 0.01).
These results demonstrate that prohepcidin levels are reduced in patients with HBV-related cirrhosis and are an independent correlate of serum ferritin.

• 出版日期2010-12