Mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium and deposition and release of cefazolin sodium/chitosan films

作者：Cheng Su; Wei Daqing^*; Zhou Yu

来源：Applied Surface Science, 2011, 257(7): 2657-2664.

DOI：10.1016/j.apsusc.2010.10.038

• Titanium
• Sphene
• Cefazolin sodium
• Chitosan
• Microarc oxidation
• Heat-treatment

The mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium formed by a hybid technique of microarc oxidation (MAO) and heat-treatment were investigated. The results indicated that the heat-treatment could improve the hardness, elastic modulus, elastic recovery and corrosion resistance of the MAO coatings, and reinforce the interface bonding between MAO coatings and titanium. A cefazolin sodium/chitosan drug film was prepared on the coating surfaces. The drug load procedures such as the addition of chitosan obviously increased the sustained-release ability of drug films. In addition, the increase of cefazolin sodium concentration could increase the accumulative release concentration of cefazolin sodium. The sustaining-release ability of drug films deposited on the MAO and heat-treated MAO coatings is similar. In the interior of drug film, the physical and chemical bonding reactions such as Coulombic interactions, van der Waals force and H-bonding etc. could be produced, through the chemical group interactions such as -OH and -NH(2) groups of chitosan with -C=O of cefazolin sodium.

• 出版日期2011-1-15
• 单位哈尔滨工业大学