Abyssomicin I, a Modified Polycyclic Polyketide from Streptomyces sp. CHI39

作者:Igarashi Yasuhiro*; Yu Linkai; Miyanaga Satoshi; Fukuda Takao; Saitoh Noriko; Sakurai Hiroaki; Saiki Ikuo; Alonso Vega Pablo; Trujillo Martha E
来源:Journal of Natural Products, 2010, 73(11): 1943-1946.
DOI:10.1021/np100292h

摘要

Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC(50) values of 11 and 0.21 mu M, respectively.

  • 出版日期2010-11