APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status

作者：Snejdrlova Michaela^*; Kalvach Zdenek; Topinkova Eva; Vrablik Michal; Prochazkova Renata; Kvasilova Marie; Lanska Vera; Zlatohlavek Lukas; Prusikova Martina; Ceska Richard

来源：Neuroendocrinology Letters, 2011, 32: 51-54.

• apolipoprotein E
• life expectancy
• gene polymorphism
• functional fitness
• frailty

OBJECTIVES: Life expectancy is determined by a combination of genetic predisposition (similar to 25%) and environmental influences (similar to 75%). Nevertheless a stronger genetic influence is anticipated in long-living individuals. Apolipoprotein E (APOE) gene belongs among the most studied candidate genes of longevity. We evaluated the relation of APOE polymorphism and fitness status in the elderly.
MATERIAL AND METHODS: We examined a total number of 128 subjects, over 80 years of age. Using a battery of functional tests their fitness status was assessed and the subjects were stratified into 5 functional categories according to Spirduso's classification. Biochemistry analysis was performed by enzymatic method using automated analyzers. APOE gene polymorphism was analysed performed using PCR-RFLP.
RESULTS: APOE4 allele carriers had significantly worse fitness status compared to non-carriers (p=0.025). Multiple logistic regression analysis showed the APOE4 carriers had higher risk (p=0.05) of functional unfitness compared to APOE2/E3 individuals.
CONCLUSIONS: APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly. While APOE2 carriers tend to remain functionally fit till higher age, the functional status of APOE4 carriers deteriorates more rapidly.

• 出版日期2011