Direct Arylation of Heteroaromatic Compounds with Congested, Functionalised Aryl Bromides at Low Palladium/Triphosphane Catalyst Loading

作者：Roy David; Mom Sophal; Lucas Dominique; Cattey Helene; Hierso Jean Cyrille^*; Doucet Henri

来源：Chemistry - A European Journal, 2011, 17(23): 6453-6461.

DOI：10.1002/chem.201100100

• aryl bromides
• C-H activation
• ferrocenyl polyphosphane
• heterocycles
• palladium

A new ferrocenyl triphosphane ligand associated to palladium was found to be an efficient catalyst for the direct coupling of highly congested, functionalised aryl bromides with a variety of heteroarenes. These coupling reactions can generally be performed by using a low-loading (0.1-0.5 mol%) of the catalyst. The present protocol tolerates important and useful functional groups, which allows for further elaboration into more sophisticated heterocyclic molecules. The straight-forward arylation of heteroaromatic compounds with congested ortho-substituted aryl bromides may permit further convergent syntheses of diverse ligands, biologically active molecules and molecular materials in only a few steps.

• 出版日期2011-5