Dehydroevodiamine center dot HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats

作者：Kim Hee Jin; Shin Ki Young; Chang Keun A; Ahn Sangzin; Choi Hee Soon; Kim Hye Sun; Suh Yoo Hun^*

来源：Korean Journal of Physiology and Pharmacology, 2014, 18(1): 55-59.

DOI：10.4196/kjpp.2014.18.1.55

• Depression
• DHED
• Fluoxetine
• Memory
• Stress

Dehydroevodiamine center dot HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.

• 出版日期2014-2