Duration of untreated psychosis and cognitive deficits in a cohort of chronic psychotic patients

作者：Primavera D; Carta R; Lepori T; Sanna L; Carpiniello B^*

来源：Clinica Terapeutica, 2013, 164(4): E263-E271.

DOI：10.7417/CT.2013.1586

• bipolar disorders
• duration of untreated psychosis
• cognitive functioning
• cognitive deficits
• psychotic disorders
• schizophrenia
• schizoaffective disorders

Aims. Outcome of psychotic disorders, particularly schizophrenia and related disorders, seems to be associated, among a number of other factors, to the latency of treatment of irst episode (duration of untreated psychosis, DUP); indeed, outcome seems to be worse in subjects with a longer DUP. However, few studies addressed the topic of long term outcome and DUP as regard to cognitive functioning, though the latter plays a crucial role in explaining a significant proportion of disability both in non-affective and affective psychoses. The study aims to analyze relationships between DUP and cognitive functioning in a sample of chronic psychotic patients. %26lt;br%26gt;Materials and Methods. We considered a unselected sample constituted by 82 chronic outpatients, 49 males (59,8%) e 33 females (40,2%), age range 20-74 yrs (mean age 46,59; s. d. 10,68 yrs); these patients were affected by schizofrenia (n=41, 50%), Bipolar Disorder type I, with psychotic mood congruent or uncongruent features (n=18, 22%,) and Schizoaffettive Disorder (n=23, 28%) according to DSMIVTR, with diagnosis confirmed by means of SCID-I. Patients underwent WAIS-R in order to evaluate cognitive functioning. %26lt;br%26gt;Results. A longer DUP (more than 3 months between onset of first clinically evident psychotic symptoms and first antipsychotic treatment) was associated with significantly lower scores in 9 out of 11 subtests of WAIS, weighted total score, IQ-verbal score, IQ-performance score and IQ-total score. A significant relationship between a longer DUP and lower cognitive performances was confirmed among schizophrenic and schizoaffective patients, although limited to some subtests. %26lt;br%26gt;Conclusions. The study provides new evidence for a positive association between longer DUP and worse neurocognitive functioning, even in the long term.

• 出版日期2013