An easy route to exotic 9-epimers of 9-amino-(9-deoxy) cinchona alkaloids with (8S, 9R) and (8R, 9S)-configurations through two inversions of configuration

作者：Wan Jing Wei; Ma Xue Bing^*; He Rong Xing; Li Ming

来源：Chinese Chemical Letters, 2014, 25(4): 557-560.

DOI：10.1016/j.cclet.2013.12.008

• Cinchona alkaloids
• 9-Amino-(9-deoxy) cinchona alkaloids
• Synthesis
• Inversion of configuration

Four exotic chiral organocatalysts, 9-amino-(9-deoxy) cinchona alkaloids with (8S, 9R) and (8R, 9S)-configurations, were conveniently synthesized for the first time in 27-72% total yields through two conversions of configuration at the 9-stereogenic centers of commercially available cinchona alkaloids.

• 出版日期2014-4
• 单位西南大学