Application of beta-(2-Chloroaroyl)thioacetanilide in Synthesis(III): An Efficient Three-Component Synthesis of Thiochromeno[2,3-b]pyridines Catalyzed by KF/Neutral Al2O3 Co-operated with PEG 6000 under Microwave Irradiation

作者：Wen Lirong; Ji Chen; Li Yafeng; Li Ming^*

来源：Journal of Combinatorial Chemistry, 2009, 11(5): 799-805.

DOI：10.1021/cc800136s

A series of new functionalized thiochromenol[2,3-b]pyridine derivatives have been synthesized via a sequence of Knoevenagel condensation, Michael addition, cyclization, and intramolecular nucleophilic substitution, which is first catalyzed by KF/neutral Al2O3 cooperated with PEG 6000 under microwave irradiation. Experimental results indicated that among the catalysts tested, KF/neutral Al2O3 with PEG 6000 exhibits the best catalytic activity, which leads to a substantial improvement in the overall yield and purity of the desired final products and significantly shorter reaction time.

• 出版日期2009-10
• 单位青岛科技大学