Direct ortho-Hydroxylation of 2-Phenylpyridines using Palladium(II) Chloride and Hydrogen Peroxide

作者：Yamaguchi Tomoaki; Yamaguchi Eiji; Tada Norihiro; Itoh Akichika^*

来源：Advanced Synthesis & Catalysis, 2015, 357(9): 2017-2021.

DOI：10.1002/adsc.201500061

• C-H activation
• hydroxylation
• palladium
• peroxides

Direct functionalization of the ubiquitous C-H bond is receiving much attention because complex structures can be formed from simple precursors. This paper reports a useful method for the direct hydroxylation of 2-phenylpyridines using palladium(II) chloride and aqueous hydrogen peroxide. In this method, hydrogen peroxide, which has high atom efficiency, is employed as the oxidant and phenol derivatives are generated via C-H activation.

• 出版日期2015-6-15