A Corey-Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bis(bibenzyl) Analogue

作者：Almalki Faisal A; Harrowven David C^*

来源：European Journal of Organic Chemistry, 2016, 2016(34): 5738-5746.

DOI：10.1002/ejoc.201601179

• Natural products
• Total synthesis
• Macrocycles
• Cyclization
• Polycycles

A total synthesis of riccardin C has been accomplished using a Corey-Seebach reaction to effect macrocyclisation. The versatility of the strategy has also been demonstrated with a mimetic synthesis of an unnatural bis(bibenzyl) analogue.