An ortho-substituted BIPHEP ligand and its applications in Rh-catalyzed hydrogenation of cyclic enamides

作者：Tang WJ; Chi YX; Zhang XM^*

来源：Organic Letters, 2002, 4(10): 1695-1698.

DOI：10.1021/ol0258435

[GRAPHICS]
An ortho-substituted BIPHEP ligand, o-Ph-hexaMeO-BIPHEP (1), is designed and synthesized. Compared with chiral biaryl phosphines without ortho substituents such as BINAP and MeO-BIPHEP, o-Ph-hexaMeO-BIPHEP shows higher enantioselectivities in Rh-catalyzed hydrogenation of cyclic enamides.

• 出版日期2002-5-16