Access to enantioenriched 2,3-and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction

作者：Borrajo Calleja Gustavo M; Bizet Vincent; Buergi Thomas; Mazet Clement^*

来源：Chemical Science, 2015, 6(8): 4807-4811.

DOI：10.1039/c5sc01460c

A palladium-catalyzed intermolecular asymmetric Heck reaction with dihydrofurans with a trisubstituted double bond is reported. The use of two different chiral ligands provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enantiocontrol.

• 出版日期2015