Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice

作者：Vieira Larissa Fernanda de A; Reis Maria Danielma dos S; Brandao Altair Rogerio A; Viana Iana Mayane M N; da Silva Juliane Pereira; Barreto Emiliano; Smaniotto Salete^*

来源：Brazilian Journal of Pharmacognosy, 2013, 23(4): 680-686.

DOI：10.1590/S0102-695X2013005000044

• Bowdichia virgilioides
• anxiety
• elevated plus maze
• open field
• rota rod

Current therapeutic for the treatment of anxiety is associated with a wild variety of side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. Bowdichia virgilioides Kunth, Fabaceae, is a plant commonly employed in the Brazilian folk medicine to treat inflammatory conditions. Nevertheless, despite its popular use there are no studies related to its possible neuropharmacological effect. Here, we investigated the possible anxiolytic effect of the extract of B. virgilioides after acute and sub-chronic treatment in mice. The aqueous extract from the stem barks of B. virgilioides (20, 200 or 400 mg/kg) was orally administered, and its anxiolytic effect was evaluated in the elevated plus maze, open-field and rota-rod tests. Diazepam was employed as standard drug. The aqueous extract treatment was effective in inducing anxiolytic effects with single acute treatment, a phenomenon that remained after chronic treatment. However, no changes in spontaneous locomotor activity or myorelaxant effect after aqueous extract treatment. The extract was either safe with no deaths in mice treated orally with 1000 mg/kg. These findings suggest that the aqueous extract from the stem barks of Bowdichia virgilioides has an acute and sub-chronic anxiolytic-like effect without compromising motor activity, demonstrating an advantage regarding to antidepressant drugs.

• 出版日期2013-8