Development of a general Pd(II) - Catalyzed intermolecular hydroalkoxylation reaction of vinylphenols by using a sacrificial alcohol as the hydride source

作者：Zhang Yang^*; Sigman Matthew S

来源：Organic Letters, 2006, 8(24): 5557-5560.

DOI：10.1021/ol062222t

A general hydroalkoxylation of vinylphenols has been successfully developed wherein primary, secondary, and tertiary alcohols can be used as nucleophiles. The key conceptual breakthrough is the use of sec-phenethyl alcohol at relatively low concentrations as the sacrificial alcohol to undergo oxidation and provide the proposed Pd-H intermediate.

• 出版日期2006-11-23