Changes in plasma IL4, TNF芍 and CRP in response to regular passive smoking at home among healthy school children in Khartoum, Sudan

作者：TH Merghani; A Saeed; A Alawad

来源：African Health Sciences, 2012.

Background: Regular exposure to tobacco smoke at home causes airway inflammation and altered cytokine regulation; however, there is variation between individuals of different countries. Objective: To determine effects of passive smoking on plasma IL4, TNF芍, and CRP in healthy male school-children in Khartoum. Methods: A total of 135 male school-pupils (69 passive smokers and 66 non-smokers) were selected randomly from three primary schools for boys in Khartoum. Information about smoking history was collected from each pupil and his parents using a questionnaire. Plasma CRP, IL4 and TNF芍 were measured using commercially available ELISA kits. Results: Plasma IL4 and TNF芍 in the passive smokers (mean ㊣ SEM) is at 2.92 ㊣ 0.93 and 19.78 ㊣ 4.67 pg/ml respectively; whereas in the non-smokers . It is at 0.45 ㊣ 0.28 and 5.05 ㊣ 1.54 pg/ml respectively. The difference between the two groups is statistically significant (p %26lt;0.05). The mean plasma IL4 and TNF芍 were lowest with no exposure, higher with moderate exposure, and highest with heavy exposure (P %26lt; 0.05). Plasma CRP showed insignificant difference between the two groups. Conclusion: Passive smoking causes significant rise in plasma TNF芍 and IL4 with a dose dependent effect among schoolpupils in Khartoum.

• 出版日期2012