Autoimmune uveitis: The associated proinflammatory molecules and the search for immunoregulation

作者：Commodaro Alessandra Goncalves; Bueno Valquiria; Belfort Rubens Jr; Rizzo Luiz Vicente^*

来源：Autoimmunity Reviews, 2011, 10(4): 205-209.

DOI：10.1016/j.autrev.2010.10.002

• Autoimmune uveitis
• EAU
• Immune response
• Inflammatory molecules
• Immunoregulation

Uveitis is an intraocular inflammatory disease causing a significant visual impairment. The disease can be idiopathic, associated with infectious and systemic disorders or arisen from an unknown cause. Over the last 20 years the model of EAU in mice has contributed significantly for the establishment of parameters for diagnostic evaluations and therapies for posterior uveitis in human. Many studies using recently discovered molecules which present proinflammatory and anti-inflammatory effects have been described. Moreover, new approaches of research provided by the increasing body of knowledge on components of immune responses such as cytokines, 1-cell subpopulations and their associated functions have contributed for the further understanding of uveitis and possible treatment.

• 出版日期2011-2