Adenosine-glutamate receptor-receptor interactions in the central nervous system

作者：Ciruela F^*; Escriche M; Soloviev MM; Canela EI; Burgeno J; Mallol J; Chan WY; Lluis C; McIlhinney RA; Franco R

来源：Drug Development Research, 2001, 52(1-2): 316-322.

DOI：10.1002/ddr.1129

• adenosine A1 receptor
• mGlu(1 alpha) receptor
• Homer
• protein-protein interaction

Glutamate is the major excitatory neurotransmitter in the central nervous system and its function through ionotropic and metabotropic glutamate receptors can he modulated by other neurotransmitters/neuromodulators. Recently, evidence has emerged that seven transmembrane G-protein-coupled receptors (GPCRs) may be present as homo- and heteromers in the plasma membrane. Here we propose a new molecular and functional interaction between two unrelated types of GPCR, namely the metabotropic glutamate type 1 alpha and the adenosine A1 receptors in the central nervous system. Apart from providing a molecular basis for adenosine/glutamate receptor cross-talk, this interaction may lead to the development of novel reagents to treat neuropsychiatric disorders in which abnormal glutamatergic neurotransmission is involved. Drug Dev. Res. 52:316-322, 2001.

• 出版日期2001-2