A randomized clinical trial of two emergency contraceptive pill regimens in a Ugandan population

作者：Byamugisha Josaphat K^*; Mirembe Florence M; Faxelid Elisabeth; Tumwesigye Nazarius M; Gemzell Danielsson Kristina

来源：Acta Obstetricia et Gynecologica Scandinavica, 2010, 89(5): 670-676.

DOI：10.3109/00016341003611220

• Emergency contraceptive pills
• levonorgestrel
• Ugandan

Background. Recent trials on emergency contraception (EC) have indicated that levonorgestrel (LNG) used alone has fewer side-effects and is more efficacious than the Yuzpe regimen (high dose combined oral contraceptive pills). However, the experienced side-effects and acceptability may vary between different groups or societies. Objective. The primary objective of this study was to determine side-effects and acceptability of two emergency contraceptive pill (ECP) regimens among users in Kampala, Uganda. Study design. Randomized clinical trial. Methods. A total of 337 women were enrolled in a double blind randomized clinical trial. Women requesting ECPs within 72 hours after unprotected sexual intercourse received either LNG or the Yuzpe regimen. The women returned for follow-up after three days and a follow-up interview was performed after one year. Results. Levonorgestrel had significantly fewer side-effects than the Yuzpe regimen (p < 0.001). There was a significant association between having worries about the method and experiencing side-effects (p < 0.001). Most women (81%) were prime users of EC. The majority would recommend ECP to other clients. Conclusions. Levonorgestrel is a superior option to the Yuzpe regimen and should be promoted as the recommended ECP. Having worries about ECP may influence experience of the side-effects. Correct information is critical in promotion of ECP use.

• 出版日期2010-5