MR-elastography reveals degradation of tissue integrity in multiple sclerosis

作者：Wuerfel Jens; Paul Friedemann; Beierbach Bernd; Hamhaber Uwe; Klatt Dieter; Papazoglou Sebastian; Zipp Frauke; Martus Peter; Braun Juergen; Sack Ingolf^*

来源：NeuroImage, 2010, 49(3): 2520-2525.

DOI：10.1016/j.neuroimage.2009.06.018

• Multiple sclerosis
• MRI
• Magnetic resonance elastography
• Viscoelasticity
• Brain
• Gender

In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation is increasingly recognized to be present from the very onset of the disease, and, although occult to conventional imaging techniques, may present a major Cause of permanent neurological disability. Subtle tissue alterations significantly influence biomechanical properties given by stiffness and internal friction, that - in more accessible organs than the brain - are traditionally assessed by manual palpation during the clinical exam. The brain, however, is protected from our sense of touch, and thus Our current knowledge oil cerebral viscoelasticity is very limited. We developed a clinically feasible magnetic resonance elastography setup sensitive to subtle alterations of brain parenchymal biomechanical properties. Investigating 45 MS patients revealed a significant decrease (13%. P<0.001) of cerebral viscoelasticity compared to matched healthy volunteers, indicating a widespread tissue integrity degradation, while structure-geometry defining parameters remained unchanged.

• 出版日期2010-2-1
• 单位河北医科大学