Asymmetric synthesis of tricyclic tetralin derivatives via an intramolecular photoreaction

作者：Yang Chao; Xia Wu Jiong^*; Scheffer John R

来源：Tetrahedron, 2007, 63(29): 6791-6795.

DOI：10.1016/j.tet.2007.04.072

An intramolecular photoreaction for the synthesis of tricyclic tetralin derivatives through a Norrish/Yang type cyclization is described. Asymmetric studies on this reaction using ionic chiral auxiliaries gave enantiomeric excesses of up to 99% at conversions of 80%, and the reaction mechanism was mapped out by a single crystal-to-single crystal reaction.

• 出版日期2007-7-16
• 单位哈尔滨工业大学