Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria

作者：Chen, Jinyun; Wang, Qian; Feng, Xuebing; Zhang, Zhuoya; Geng, Linyu; Xu, Ting; Wang, Dandan; Sun, Lingyun^*

来源：Stem Cells International, 2016, 2016: 4062789.

DOI：10.1155/2016/4062789

• DEATH
• APOPTOSIS
• AUTOIMMUNITY
• INDUCTION
• PROMOTES
• THERAPY
• MIRO1

Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). In this study, we showed that T cells from SLE patients had higher autophagic activity than that from healthy controls. A correlation between autophagic activity and apoptotic rate was observed in activated T cells. Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) could inhibit respiratory mitochondrial biogenesis in activated T cells to downregulate autophagy and consequently decrease T cell apoptosis through mitochondrial transfer and thus may play an important role in SLE treatment.

• 出版日期2016
• 单位南京大学; 苏州大学; 南京医科大学