Duboscic Acid: A Potent alpha-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from Duboscia macrocarpa

作者：Wafo Pascal^*; Kamdem Ramsay S T; Ali Zulfiqar; Anjum Shazia; Khan Shamsun Nahar; Begum Afshan; Krohn Karsten; Abegaz Berhanu M; Ngadjui Bonaventure T; Choudhary Muhammad Iqbal

来源：Organic Letters, 2010, 12(24): 5760-5763.

DOI：10.1021/ol1026552

Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name "dubosane" is proposed. Duboscic acid has a potent a-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.

• 出版日期2010-12-17