Hydrogel Nanoparticles with Covalently Linked Coomassie Blue for Brain Tumor Delineation Visible to the Surgeon

作者：Nie, Guochao; Hah, Hoe Jin; Kim, Gwangseong; Lee, Yong Eun Koo; Qin, Ming; Ratani, Tanvi S; Fotiadis, Panagiotis; Miller, Amber; Kochi, Akiko; Gao, Di; Chen, Thomas; Orringer, Daniel A; Sagher, Oren; Philbert, Martin A; Kopelman, Raoul^*

来源：Small, 2012, 8(6): 884-891.

DOI：10.1002/smll.201101607

• cancer therapy
• hydrogels
• nanoparticles
• tumor delineation
• visible contrast

Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor-targeting deep-blue nanoparticle-based visible contrast agent is described, which, for the first time, offers in vivo tumor-specific visible color staining. This technology thus enables color-guided tumor resection in real time, with no need for extra equipment or special lighting conditions. The visual contrast agent consists of polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue color contrast), which are surface-conjugated with polyethylene glycol and F3 peptides for efficient in vivo circulation and tumor targeting, respectively.

• 出版日期2012-3
• 单位玉林师范学院