Applications of alpha-Phosphonovinyl Tosylates in the Synthesis of alpha-Arylethenylphosphonates via Suzuki-Miyaura Cross-Coupling Reactions

作者：Fang, Yewen^*; Zhang, Li; Li, Jinjian; Jin, Xiaoping; Yuan, Meijuan; Li, Ruifeng; Wu, Rong; Fang, Jianghua

来源：Organic Letters, 2015, 17(4): 798-801.

DOI：10.1021/ol503518h

• ENANTIOSELECTIVE HYDROGENATION
• PALLADIUM CATALYST
• ARYLBORONIC ACIDS
• ARYL
• PHOSPHONATES
• CHLORIDES
• REAGENTS
• ETHERS

It has been demonstrated for the first time that alpha-phosphonovinyl tosylates could efficiently couple with a range of arylboronic acids to access alpha-arylethenylphosphonates. The unprecedented procedure exhibits excellent functional group tolerance, giving the terminal vinylphosphonates in good to excellent isolated yields (60-99%) under mild reaction conditions.

• 出版日期2015-2-20
• 单位太原理工大学; 浙江医药高等专科学校; 宁波工程学院