A new synthesis of five-membered heterocyclic quorum sensing inhibitors

作者：Benneche Tore^*; Chamgordani Elahe Jafari; Reimer Inga

来源：Tetrahedron Letters, 2012, 53(51): 6982-6983.

DOI：10.1016/j.tetlet.2012.10.048

• Brominated furanones
• Thiophenones and pyrrolones
• Quorum sensing inhibitors
• Bromide cleavage of carbon-oxygen bonds

5-(Bromoalkylidene)furan-2(5H)-ones, thiophen-2(5H)-ones, and pyrrol-2(5H)-ones are prepared in good yields by cleavage of the corresponding 2-acyl-5-methoxy heterocycles using oxalyl bromide in dichloromethane at ambient temperature.

• 出版日期2012-12-19