Protection against filovirus infection: virus-like particle vaccines

作者：Yang Chinglai^*; Ye Ling; Compans Richard W

来源：Expert Review of Vaccines, 2008, 7(3): 333-344.

DOI：10.1586/14760584.7.3.333

• antibody
• Ebola
• filovirus
• innate immunity
• Marburg
• natural killer cell
• T cell
• therapeutic treatment
• vaccine
• virus-like particle

Significant progress has been made in vaccine development against infection by Ebola and Marburg viruses, members of the Filoviridae, which cause severe hemorrhagic fevers in humans with no effective treatment and a mortality rate of up to 90%. Several vaccine strategies have been shown to effectively protect immunized animals against filovirus infection. Among these candidate vaccine strategies, virus-like particles represent a promising approach and have been shown to protect small laboratory animals as well as nonhuman primates against lethal challenge by Ebola and/or Marburg viruses. This review briefly summarizes filovirus epidemiology and pathogenesis, and focuses on the discussion of recent advances in filovirus vaccine development and the current understanding of protective immune responses against filovirus infection with an emphasis on the progress and challenge of filovirus virus-like particle vaccine development.

• 出版日期2008-4