Association Between Genetic Polymorphisms in the Promoter Regions of Let-7 and Risk of Papillary Thyroid Carcinoma A Case-Control Study

作者：Wang Yichao; Wei Tao; Xiong Junjie; Chen Peng; Wang Xunli; Zhang Lin; Gao Linbo; Zhu Jingqiang^*

来源：Medicine, 2015, 94(43): e1879.

DOI：10.1097/MD.0000000000001879

The aim of this study was to investigate the association between 2 polymorphisms (ie, rs10877887 and rs13293512) in the promoter regions of let-7 and the risk of papillary thyroid carcinoma (PTC).A case-control study of 618 PTC patients and 562 controls was conducted. The rs10877887 polymorphism was genotyped by using polymerase chain reaction-restriction fragment length polymorphism and the rs13293512 polymorphism was genotyped by using a TaqMan Genotyping Assay. The results were confirmed by DNA sequencing.The rs10877887 polymorphism had reduced risks of PTC in heterozygous comparison, dominant model, and overdominant model (TC vs TT: adjusted odds ratio [OR]=0.73, 95% confidence interval [95% CI]=0.58-0.94, P=0.01; TC/CC vs TT: adjusted OR=0.79, 95% CI=0.63-1.00, P=0.047; TC vs TT/CC: adjusted OR=0.73, 95% CI=0.57-0.92, P=0.007, respectively). Stratified analyses showed that PTC patients carrying the rs10877887 CC genotype were more likely to have multiple tumors (adjusted OR=1.71, 95% CI=1.03-2.86, P=0.04), and PTC patients carrying the rs13293512 TC+CC or CC were more likely to develop N0 status (TC/CC vs TT: adjusted OR=0.64, 95% CI=0.43-0.94, P=0.02; CC vs TC/TT: adjusted OR=0.50, 95% CI=0.33-0.77, P=0.001, respectively).Our study suggests that the rs10877887 polymorphism may be associated with the risk of PTC and the rs13293512 polymorphism may correlate to lymph node metastasis in PTC.

• 出版日期2015-10
• 单位四川大学