Antituberculosis activity of the molecular libraries screening center network library

作者：Maddry Joseph A^*; Ananthan Subramaniam; Goldman Robert C; Hobrath Judith V; Kwong Cecil D; Maddox Clinton; Rasmussen Lynn; Reynolds Robert C; Secrist John A III; Sosa Melinda I; White E Lucile; Zhang Wei

来源：Tuberculosis, 2009, 89(5): 354-363.

DOI：10.1016/j.tube.2009.07.006

• MLSCN
• TAACF
• Antitubercular
• High-throughput screening
• Medicinal chemistry analysis
• Small molecule chemical library
• Tuberculosis

There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.

• 出版日期2009-9